3-Lower alkoxycyproheptadines as serotonin inhibitors

Details 3-Lower alkoxycyproheptadines as serotonin inhibitors 3-Lower alkoxycyproheptadines as serotonin inhibitors

1976-08-12

1978-08-01

Jaisle, Cecilia M. S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

26029362, C07D21170, A61K 31445

Patent

active

041043987

ABSTRACT:
The levorotatory enantiomers of 3-loweralkoxy-cyproheptadines are potent antiserotonin agents with a lower order of antihistaminic activity and substantially free of any anticholinergic activity. They are prepared by treatment of the levorotatory enantiomer of 3-iodocyproheptadine with an alkali metal lower alkoxide in the presence of copper powder.

REFERENCES:
patent: 3014911 (1961-12-01), Engelhardt
Houben-Weyl, Methoden d. Org. Chem.: Sauerstoff-Verbindungen I, Teil 3, pp. 75-79.

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