3-ketoacyl-ACP-reductase (FabG) of Staphylococcus aureus

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4352523, 4353201, 435325, 536 231, 536 235, C12P 2100, C12N 121, C12N 1563, C12N 1585, C12N 1586

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active

061107042

ABSTRACT:
The invention provides fabG polypeptides and polynucleotides encoding fabG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing fabG polypeptides to screen for antibacterial compounds.

REFERENCES:
patent: 5700928 (1997-12-01), Hodgson et al.
Fleishmann et al. Science 269:496-512, see abstract for statement of Accession No., Jul. 1995.
Fleishmann et al. GenEmbl Accession No. U32701 L42023, Jul. 1995.
Cronan, et al., "The Gene Encoding Escerichia coli Acyl Carrier Protein Lies Within a cluster of Fatty Acid Biosynthetic Genes.", GenBank Submission, Accession No. M84991, Released Apr. 2, 1992.
Rawlings, et al., "The Gene Encoding Escherichia coli Acyl Carrier Protein Lies Within a cluster of Fatty Acid Biosynthetic Genes.", The Journal of Biological Chemistry, vol. 267, No. 9, pp. 5751-5754, (1992).
Morbidoni, et al, "Bacillus subtillis acyl carrier protein is encoded in a cluster of lipid biosynthesis genes.", Journal of Bacteiology, Aug. 1996, vol. 178, No. 16 pp. 4794-4800.
International search report from corresponding International patent application number PCT/US00/01196.

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