Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1984-12-27
1986-09-02
Fan, Jane T.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546270, 546256, 514333, 514338, 514339, C07D40104
Patent
active
046097333
ABSTRACT:
Disclosed is a process for the preparation of a compound of the formula ##STR1## wherein Ar is 3- or 4-pyridyl or 3- or 4-pyridyl substituted by lower alkyl; R.sub.1 is hydrogen, halogen, trifluoromethyl, lower alkyl, hydroxy, acylated or etherified hydroxy, lower alkylthio; or two of R.sub.1 on adjacent carbon atoms represent alkylenedioxy; p is 1 or 2; R.sub.2 represents hydrogen or lower alkyl; E represents C.sub.1 -C.sub.11 alkylene, C.sub.1 -C.sub.6 alkylenephenylene, C.sub.1 -C.sub.6 alkylene-(thio or oxy)-lower alkylene, C.sub.1 -C.sub.6 alkylene-(thio or oxy)-phenylene, C.sub.1 -C.sub.6 alkylenephenylene-lower alkylene, phenylene-lower alkylene; or E represents a direct bond; and B represents carboxy, esterified carboxy or carbamoyl; which comprises deoxygenating the keto group in a compound of the formula ##STR2## wherein Ar, R.sub.1, R.sub.2, p, E and B have meaning as defined above.
REFERENCES:
patent: 3449348 (1969-06-01), Shen et al.
patent: 3933853 (1976-01-01), Demarne
patent: 4322533 (1982-03-01), Lesher et al.
patent: 4363912 (1982-12-01), Cross et al.
patent: 4416895 (1983-11-01), Thorogood
patent: 4451472 (1984-05-01), Cross et al.
patent: 4460777 (1984-07-01), Renfroe
patent: 4478842 (1984-10-01), Renfroe
patent: 4511573 (1985-04-01), Renfroe
patent: 4536505 (1985-08-01), Browne
Demarne, Chem. Abst. 3381n, vol. 80, 1974 and Chem. Abst. 59863p, vol. 80, 1974.
Khan et al., J. Chem. Soc. (C), 1970, p. 85.
A. H. Jackson et al., Chemical Communications, 1967, 264-266.
R. O. Hutchins et al--Amine Boranes Review, Organic Preparations and Procedures Int. 16(5), 335-372 (1984).
J. F. Stoddart, editor, Comprehensive Organic Chemistry, 1979, vol. 1, pp. 1079-1081.
Bach Joseph
Boyer Stephen K.
Gelotte Karl O.
Ciba-Geigy Corporation
Fan Jane T.
Gruenfeld Norbert
LandOfFree
3-keto-substituted-N-pyridylindoles does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 3-keto-substituted-N-pyridylindoles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-keto-substituted-N-pyridylindoles will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1098248