3-keto-nor-pregnenes substituted in the 6-position and treatment

Details 3-keto-nor-pregnenes substituted in the 6-position and treatment 3-keto-nor-pregnenes substituted in the 6-position and treatment

1996-05-06

1998-08-18

Cook, Rebecca

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

552539, 552593, A61K 3156, C07J 500

Patent

active

057958840

ABSTRACT:
A 3-keto-19-nor-pregnene of the formula ##STR1## wherein R is selected from the group consisting of hydroxy, acyloxy of an organic carboxylic acid, lower alkoxy, halogen and lower alkyl, R' is selected from the group consisting of hydrogen and halogen, or R and R' together form oxygen, R.sub.3 is selected from the group consisting of methyl, --OH and lower acyloxy of an organic carboxylic acid and the dotted line is an optional double bond in the 6,7-position useful for treating the symptoms of menopause in females.

REFERENCES:
Dorai et al, J. Pharmacol. & Exper. Ther., pp. 620-625, 1991.
Gilbert et al, Steroids, vol. 23, No. 4., Apr. 1973 pp. 585-607.
CA 77: 48724, Anney, 1971.
CA 115: 175 131, Dorai et al, 1991.

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