Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1984-12-12
1986-04-08
Schwartz, Richard A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
2602457, 514323, 514414, 546201, 546223, 548467, A61K 3155, C07D40112
Patent
active
045813558
ABSTRACT:
3-Indolecarboxamide compounds of the formula: ##STR1## inclusive of pharmaceutically acceptable acid addition salt and/or hydrate forms thereof, wherein R.sup.1 is hydrogen or C.sub.1-4 alkyl; each of R.sup.2 and R.sup.3 is hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, benzyloxy, C.sub.2-6 alkanoyloxy or hydroxy; R.sup.4 is hydrogen or C.sub.1-4 alkyl; R.sup.5 is hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or hydroxy; R.sup.6 is hydrogen or C.sub.1-4 alkyl; X is oxygen, sulfur or direct bond; each of k and m is an integer of 1 to 3; and n is 1 or 2, are useful as drug for the prevention and treatment of various circulatory diseases.
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patent: 4064255 (1977-12-01), Champselx et al.
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March, Advanced Organic Chemistry, 1st ed., McGraw-Hill, 1968, p. 336.
Archibald, J., et al., Journal of Medicinal Chemistry, vol. 14, pp. 1054-1059, (1971).
Ikebe Tsuguo
Maruyama Yutaka
Miura Yohji
Tahara Tetsuya
Yaoka Osamu
Schwartz Richard A.
Yoshitomi Pharmaceutical Industries Ltd.
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