3-imidazolylalkyl-, triazolylalkyl-, pyridinylalkyl-1,2,3-benzot

Details 3-imidazolylalkyl-, triazolylalkyl-, pyridinylalkyl-1,2,3-benzot 3-imidazolylalkyl-, triazolylalkyl-, pyridinylalkyl-1,2,3-benzot

1986-03-03

1987-07-14

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544183, A61K 3153, C07D25308

Patent

active

046802932

ABSTRACT:
Novel 3-heteroarylalkyl-1,2,3-benzotriazin-4(3H)-ones, having the structural formula: ##STR1## wherein A is a divalent moiety of the formula: ##STR2## wherein n is an integer from 3 to 10, inclusive; R.sub.1 and R.sub.2 may be the same or different and may be selected from the group consisting of hydrogen, halogen, trifluoromethyl, alkoxy having from one to four carbon atoms, alkyl having from one to four carbon atoms, nitro and amino; wherein Heteroaryl is ##STR3## wherein R.sub.3 and R.sub.4 may be hydrogen, alkyl having from one to four carbon atoms or phenyl and X is CH or N; together with the pharmaceutically acceptable salts thereof; processes for their preparation and their use in treating prostaglandin-related vascular disorders including ischemic heart disease, transient ischemic attack, thrombosis, migraine and hypertension.

REFERENCES:
patent: 3706739 (1972-12-01), Beyerle et al.
patent: 3751413 (1973-08-01), Stachel et al.
patent: 3808318 (1974-04-01), Kathawala

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