3-imidazolyl-indoles for the treatment of proliferative...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S336000, C514S326000, C514S256000, C514S254050, C514S235800, C514S210200, C544S370000, C544S333000, C544S364000, C544S139000, C546S272700, C548S312100

Reexamination Certificate

active

08053457

ABSTRACT:
The invention relates to 3-heterocyclyl indolyl compounds of formula I capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively:whereinR1, R2, R3, R4, RA, Y and Y are as defined in the specification. Due to their activity, the compounds are useful in the treatment of various disorders and diseases mediated by the activity of MDM2 and/or MDM4, or variants thereof, such as inflammatory or proliferative diseases or in the protection of cells.

REFERENCES:
patent: 6699883 (2004-03-01), Doemling et al.
patent: WO 2006/091646 (2006-08-01), None
patent: WO 2006/136606 (2006-12-01), None
Toledo et al. Int. J. Biochem. Cell Biol. 2007, 39(7-8), 1476-1482.
Schafer et al. Drug Discovery Today 2008, 13 (21/22), 913-916.
Horig et al. Journal of Translational Medicine 2004, 2(44).
Sisko et al., “An Investigation of Imidazole and Oxazole Syntheses Using Aryl-Substituted TosMIC Reagents”, Journal of Organic Chemistry, 2000 vol. 65 No. 5 pp. 1516-1524.

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