3-hydroxypyridine-2-carboxamidoesters, their preparation and the

Details 3-hydroxypyridine-2-carboxamidoesters, their preparation and the 3-hydroxypyridine-2-carboxamidoesters, their preparation and the

1997-12-04

2000-02-01

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546296, 546298, C07D21365, C07D21389, A61K 3144

Patent

active

060203501

ABSTRACT:
There are described 3-hydrixypyridine-2-carboxamidoesters of the formula ##STR1## their preparation, their use for the inhibition of collagen biosynthesis and their use as pharmaceuticals for the treatment of fibrotic disorders.

REFERENCES:
patent: 5204338 (1993-04-01), Baader et al.
patent: 5620995 (1997-04-01), Weidmann et al.
patent: 5719164 (1998-02-01), Weidmann et al.
C. Jane Cunliffe et al., "Novel Inhibitors of Prolyl 4-Hydroxylase. 3. Inhibition by the Substrate Analogue N-Oxaloglycine and Its Derivatives", J. Med. Chem., 35, 2652-2658, (1992).
John T. Sheehan, "3-Hydroxypicolinic Acid and Some of Its Derivatives", J. Organic Chemistry, vol. 31, No. 3, 636-638, (1996).
T. J. Franklin, et al., "Approaches to the Design of Anti-Fibrotic Drugs", Biochem. Soc. Trans. vol. 19, Jul. 25, 1991, pp. 812-815.

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