3-Hydroxymethyl-7.beta.-(2-alkoxy-or benzyloxyimino-2-arylacetam

Details 3-Hydroxymethyl-7.beta.-(2-alkoxy-or benzyloxyimino-2-arylacetam 3-Hydroxymethyl-7.beta.-(2-alkoxy-or benzyloxyimino-2-arylacetam

1976-03-24

1977-07-05

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07D50132, C07D50134

Patent

active

040339505

ABSTRACT:
The invention provides novel antibiotic compounds which are 7.beta.-acylamidoceph-3-em-4-carboxylic acids, and non-toxic derivatives thereof characterized in that the acylamido group has the structure ##STR1## where R is a hydrogen atom or an organic group and R.sup.a is an etherifying monovalent organic group linked to the oxygen atom through a carbon atom. The compounds are syn isomers or exist as mixtures containing at least 75% of the syn isomer. These antibiotic compounds possess high antibacterial activity against a range of gram positive and gram negative organisms coupled with particularly high stability to .beta.-lactamases produced by various gram negative organisms. The invention is also concerned with the administration of the compounds.

REFERENCES:
Gregson et al., Chem. Abst., vol. 77; 126, 662a, (Abst. of L).
Cook et al., Ibid. vol. 78; 58,444z, (Abst. of M).

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