3-Hydroxy-propanamine derived neuronal reuptake inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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564349, A01N 3302

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active

060691778

ABSTRACT:
3-Hydroxy-propanamine derivatives and acid salts thereof having chiral centers at the C.sub.1 and C.sub.2 positions exhibit synaptosomal reuptake inhibition of neurotransmitters, and as such represent a new class of psychotropic agents useful as antidepressants.

REFERENCES:
patent: 4018895 (1977-04-01), Molloy et al.
patent: 4535186 (1985-08-01), Husbands et al.
Abstract to Carlier et al, "Anti-Selective Aldol Reaction of Benzylic Nitriles and Synthesis of gamma-Amino Alcohols", J. Org. Chem., 60(23), 7511-7517, 1995.
Carlier, P.R. et al, J. Org. Chem. 1995, 60, 7511.

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