3-Hydroxy-4,4-dimethyl-5-pyrrolidone derivatives

Details 3-Hydroxy-4,4-dimethyl-5-pyrrolidone derivatives 3-Hydroxy-4,4-dimethyl-5-pyrrolidone derivatives

1978-10-24

1980-02-05

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

26032633, 26032643, 26032645, 26032636, 560 19, 560 22, 560125, 560170, 560171, C07D20726, A61K 3140

Patent

active

041873122

ABSTRACT:
Compounds of formula (I): ##STR1## wherein: n is 4 to 8, X is CO, protected CO or CROH wherein R is hydrogen or C.sub.1-4 alkyl and wherein the OH moiety may be protected; R.sub.1 is hydrogen, or CO.sub.2 R.sub.1 represents an ester group in which the R.sub.1 moiety contains from 1 to 12 carbon atoms; R.sub.3 is hydroxy or protected hydroxy; R.sub.2 and R.sub.4 are separately hydrogen, C.sub.1-9 alkyl, C.sub.5-8 cycloalkyl, C.sub.5-8 cycloalkyl-C.sub.1-6 alkyl, phenyl, phenyl C.sub.1-6 alkyl, naphthyl, naphthyl C.sub.1-6 alkyl, any of which phenyl or naphthyl moieties may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or nitro groups; or R.sub.2 and R.sub.4 taken with the carbon atom to which they are joined represent C.sub.5-8 cycloalkyl; A is hydrogen or a group CO.sub.2 B wherein B is hydrogen, or CO.sub.2 B represents an ester group in which the B moiety contains from 1 to 12 carbon atoms; or methyl; and salts thereof; have useful pharmacological properties including anti-gastric secretion, bronchodilator and platelet aggregation inhibition activities.

REFERENCES:
patent: 3975399 (1976-08-01), de Franco et al.
patent: 4003911 (1977-01-01), Schibner
patent: 4136190 (1979-01-01), Cassidy et al.
patent: 4138407 (1979-02-01), Cassidy et al.
patent: 4138408 (1979-02-01), Metzlaff

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