3-Hydrazino-6-(pyridinyl) pyridazines and cardiotonic use thereo

Details 3-Hydrazino-6-(pyridinyl) pyridazines and cardiotonic use thereo 3-Hydrazino-6-(pyridinyl) pyridazines and cardiotonic use thereo

1980-07-28

1981-12-08

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544238, 546315, 546328, A61K 3150, C07D40104

Patent

active

043047750

ABSTRACT:
3-Hydrazino-6-PY-pyridazine or pharmaceutically-acceptable acid-addition salt thereof is useful as a cardiotonic agent, where PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substitutents. 6-PY-3-pyridazinol is prepared by reacting 6-PY-3-pyridazinol with a chlorinating agent to produce 3-chloro-6-PY-pyridazine and reacting said 3-chloro compound with hydrazine to produce said 3-hydrazino compound. 3-Hydrazino-6-PY-pyridazine or pharmaceutically-acceptable acid-addition salt thereof is disclosed as the active component in cardiotonic compositions for increasing cardiac contractility and in the method for increasing cardiac contractility in a patient requiring such treatment. The novel intermediate 3-chloro-6-PY-pyridazine is prepared as noted above.

REFERENCES:
patent: 3717365 (1973-02-01), Anderson et al.
patent: 4086343 (1978-04-01), Dori Gotti et al.
patent: 4224325 (1980-09-01), Szil agyi
Bellasio et al. Chem. Abs 75,151820 (1971).
Haginina et al. Chem. Abs 88, 170096v (1978).

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