3-Heterothio derivatives of (carbamoylthioacetyl)cephalosporins

Details 3-Heterothio derivatives of (carbamoylthioacetyl)cephalosporins 3-Heterothio derivatives of (carbamoylthioacetyl)cephalosporins

1974-08-30

1976-01-06

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602948E, 2603322A, 2603472, 260455A, 424246, C07D50150, A61K 31545

Patent

active

039311708

ABSTRACT:
3-Heterothio(carbamoylthioacetyl)cephalosporin derivatives of the general formula ##EQU1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, a salt forming ion or the group ##EQU2## R.sub.1 is hydrogen, lower alkyl, phenyl, thienyl, or pyridyl; R.sub.2 is lower alkyl or phenyl-lower alkyl; R.sub.3 is a five or six membered nitrogen, sulfur and/or oxygen containing ring system; and R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.

REFERENCES:
patent: 3391141 (1968-07-01), Gottstein et al.
patent: 3775408 (1973-11-01), Ochiai et al.
patent: 3812116 (1974-05-01), Takano et al.
Gottstein et al., J. Med. Chem., 14, No. 8, pp. 770-772, (1971).

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