3-Heterothio derivatives of (.alpha.-thiocarbonylamino) cephalos

Details 3-Heterothio derivatives of (.alpha.-thiocarbonylamino) cephalos 3-Heterothio derivatives of (.alpha.-thiocarbonylamino) cephalos

1975-05-28

1976-12-07

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603322A, 260516, 260534S, 424246, C07D50122, C07D50124, C07D50136

Patent

active

039962199

ABSTRACT:
3-Heterothio(.alpha.-thiocarbonylamino)cephalosporin derivatives of the general formula ##STR1## wherein R is hydrogen, lower alkyl, phenyl-lower alkyl, tri(lower alkyl)silyl, trihaloethyl, a salt forming ion or the group ##STR2## R.sub.1 is hydrogen, lower alkyl, cyclo-lower alkyl, unsaturated cyclo-lower alkyl, phenyl, substituted phenyl or thienyl; R.sub.2 and R.sub.5 each is hydrogen or lower alkyl; R.sub.3 is a five or six membered nitrogen, sulfur and/or oxygen containing ring system; and R.sub.4 is lower alkyl, phenyl or phenyl-lower alkyl; are useful as antibacterial agents.

REFERENCES:
patent: 3766175 (1973-10-01), Lemieux et al.
patent: 3769281 (1973-10-01), Chauvette
patent: 3819621 (1974-06-01), Morimoto et al.
patent: 3855211 (1974-12-01), Bruer et al.
Takano et al., "Chemical Abstracts," vol. 71, (1969) abst. 124,914.

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