Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Reexamination Certificate
2005-05-24
2005-05-24
McKane, Joseph K. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C546S194000, C546S223000, C546S014000, C548S131000, C548S236000, C548S110000
Reexamination Certificate
active
06897306
ABSTRACT:
Compounds of formula (I):and their salts, solvates, prodrugs, etc., wherein the substituents have the values mentioned herein, are Procollagen C-Proteinase (PCP) inhibitors and have utility in conditions mediated by PCP.
REFERENCES:
patent: 5861380 (1999-01-01), Gyorkos et al.
patent: 9705865 (1997-02-01), None
patent: 9731892 (1997-04-01), None
patent: 9945927 (1999-09-01), None
D.A. Evans et al,Journal of Organic Chemistry,vol. 64, No. 17 Aug. 20, 1999, pp. 6411-6417, “A general method for the synthesis of enantiomerically pure beta-substituted, beta-amino acids through alpha-substituted succinic acid derivatives”.
M. Yamamoto et al.,J. of Medicinal Chemistry,vol. 41, No. 8, Apr. 9, 1998, pp. 1209-1217, “Inhibition of membrane--type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket”.
D.H. Steinman et al.Bioorganic&Medicinal Chemistry Lettersvol. 8, No. 16, Aug. 18, 1998, pp. 2087-2092, “The design, synthesis and structure-activity relationships of a series of macrocyclic MMP inhibitors”.
C.B. Vu et al,Bioorganic&Medicinal Chemistry Lettersvol. 9, No. 20, Oct. 18, 1999, pp3009-3014, “Nonpeptidic SH2 Inhibitors of the Tyrosine Kinase ZAP-70”.
K. F. McClure et al.,Bioorganic&Medicinal Chemistry Lettersvol.8. No. 2, pp. 143-146, “Alkylation of succinates: synthesis of RO 32-3555, ”Alkylation of succinates: synthesis of RO 32-3555 .
B. Simoneau, et al.,Bioorganic&Medicinal Chemistry Lettersvol. 7. No. 3, pp. 489-508, “Discovery of Non-peptidic P2-P2Butanediamide Renin Inhibitors with High Oral Efficcay”.
C. D. Floyd et al., SYNLETT, No. 6, Jun. 1998, pp. 637-639, “Rapid synthesis of matrix metalloproteinase Inhibitors via Ugi four-component condensation”.
Abstract, Preparation and fromulation of hydroxamic acid detrivatives as matrix metalloproteinase inhibitors,Chemical Abstracts Service, Columbus, OH,Database accession No. 1997:594709, XP002163188.
International Search Report for PCT/IB001/01855.
Bailey Simon
Billotte Stephane
Derrick Andrew Michael
Fish Paul Vincent
James Kim
Dixon J. Michael
Djuardi Elsa
McKane Joseph K.
Pfizer Products Inc.
Wright Sonya
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