3-Heterocyclic substituted cephem compounds

Details 3-Heterocyclic substituted cephem compounds 3-Heterocyclic substituted cephem compounds

1976-05-10

1980-01-08

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, 544 16, C07D50120

Patent

active

041828666

ABSTRACT:
Novel cephem compounds having a group of the formula at the 3-position thereof: ##STR1## wherein X represents oxygen, sulfur or imino, which may be substituted; and B represents hydrogen or a hydroxyl, amino, mercapto or hydrocarbon group, which groups may be substituted, can be prepared by reacting a 3-formylcephem compound with a hydrazine compound of the formula: ##STR2## wherein the symbols have the same meanings as above, and subjecting the thus obtained compound to an oxidative ring-closure reaction. The objective compounds are found to have a broad antimicrobial spectrum and, in particular, are effective against gram-negative bacteria including Escherichia Coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus mirabilis, Proteus rettgerii, as well as gram positive ones, and have low-toxity. Thus, these compounds may be used for antimicrobial agents in therapeutical purpose.

REFERENCES:
patent: 3516997 (1970-06-01), Takano et al.
patent: 3947413 (1976-03-01), Christensen et al.
patent: 3979384 (1976-09-01), Firestone et al.
patent: 3997528 (1976-12-01), Yoshioka et al.
patent: 4007170 (1977-02-01), Berger et al.
Chemical Abstracts, vol. 82 31343m, Abstracting Ger. Offen. 2,415,402, dated 10-3-74.

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