3-heteroaralkylthio carbacephem compounds and antibacterial phar

Details 3-heteroaralkylthio carbacephem compounds and antibacterial phar 3-heteroaralkylthio carbacephem compounds and antibacterial phar

1985-11-15

1988-07-26

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514183, 514184, 514186, 514200, 514202, 514203, 514204, 514208, 540205, 540215, A61K 4340, C07D48706, C07D50114

Patent

active

047600608

ABSTRACT:
Carbacephem and cephem compounds represented by the formula: ##STR1## [Wherein X is S or CH.sub.2 ; n is an integer of 1 to 5; R.sub.1 is an unsubstituted or substituted heterocyclic group (where the heterocyclic group is a 5- or 6-membered heterocyclic group having 1 to 4 of O, S and N); R.sub.2 is a group represented by the formula: ##STR2## (where R.sub.4 is an unsubstituted or substituted phenyl or 2-aminothiazolyl) or a group represented by the formula: ##STR3## (where R.sub.5 is an unsubstituted or substituted lower alkyl); R.sub.3 is hydrogen, an alkali metal, an alkaline earth metal, an organic ammonium group or an ester residue, and R.sub.1 may be a quaternary ammonium group, where --CO.sub.2 R.sub.3 represents --CO.sub.2.sup.- ] have strong antibacterial activity against Gram-positive and Gram-negative bacteria, and are useful for treating various infections.

REFERENCES:
patent: 4123528 (1978-10-01), Cama et al.
patent: 4150156 (1979-04-01), Beattie
patent: 4226866 (1980-10-01), Christensen et al.
patent: 4256739 (1981-03-01), Woodward et al.
patent: 4278793 (1981-07-01), Durckheimer et al.
Helv. Chim. Acta., vol. 57, No. 7 (1975) 208:9.
J. Am. Chem. Soc., vol. 96, No. 15 (1974) 4986:7.
Chem. Pharm. Bull., vol. 28, No. 5 (1980) 1563:77.
Hirata et al., CA93-239247t.

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