3-Halovinylglycine antibacterial agents

Details 3-Halovinylglycine antibacterial agents 3-Halovinylglycine antibacterial agents

1986-03-17

1988-02-23

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530331, 548491, 562449, 562553, 562556, 562561, 562574, C07K 506, C07K 508, A61K 3702, C07C10110

Patent

active

047270624

ABSTRACT:
Described are 3-halovinylglycines and their amino acid dipeptide and oligopeptide conjugates, a new class of efficient antibacterial agents, pharmaceutical compositions containing them as active ingredients, and methods of synthesis. The compounds are thought to interfere in bacterial cell wall synthesis.

REFERENCES:
patent: 3960927 (1976-06-01), Metcalf et al.
Chemical Abstracts=88=6708a.
Archives of Biochem. & Biophysics, vol. 213, No. 2, 2/1982, pp. 695-707.
Antimicrobial Agents and Chemotherapy, vol. 15, No. 5, 5/1979, pp. 684-695.
Antimicrobial Agents and Chemotheraph, vol. 15, No. 5, 5/1979, pp. 677-683.
Antimicrobial Agents and Chemotherapy, vol. 18, No. 6, 12/80, pp. 897-905.
Biochemistry, vol. 17, No. 7, 1978, pp. 1313-1321.
Antimicrobial Agents and Chemotherapy, vol. 25, May '84, pp. 612-617.
Antimicrobial Agents and Chemotherapy, vol. 25, No. 5, May '84, pp. 607-611.
J. Med. Chem., 23, pp. 6-8, 1980.
J. Med. Chem., 26, pp. 1733-1741, 1983.

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