3-Halomethylcarbonyl-9-benzoyl-1,2,3,4-tetrahydrocarbazoles

Details 3-Halomethylcarbonyl-9-benzoyl-1,2,3,4-tetrahydrocarbazoles 3-Halomethylcarbonyl-9-benzoyl-1,2,3,4-tetrahydrocarbazoles

1974-02-20

1976-03-02

Winters, Sherman D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424274, C07D20986

Patent

active

039418057

ABSTRACT:
Novel 3-Z-9-benzoyl-1,2,3,4-tetrahydrocarbazoles, wherein Z is CONR.sub.5 R.sub.6, CONHOH, CN, or COCH.sub.2 X, where X is chloro or bromo, having antimicrobial and/or anti-inflammatory activity are disclosed. Compounds wherein Z is CONR.sub.5 R.sub.6 and CONHOH are prepared from the corresponding 3-carboxylic acids by conversion to the corresponding acid chlorides and subsequent reaction with the appropriate amines and hydroxylamine respectively; compounds where Z is CN are prepared by the dehydration of the corresponding compounds where Z is CONH.sub.2 ; and the compounds where Z is COCH.sub.2 X are prepared by reacting hydrogen chloride or bromide with the corresponding compounds where Z is COCHN.sub.2 which in turn is prepared from the corresponding 3-carboxylic acid chloride by reaction with diazomethane.

REFERENCES:
patent: 3655697 (1972-04-01), Shen et al.
patent: 3687969 (1972-08-01), Alexander et al.
patent: 3824314 (1974-07-01), Lacoume
Synthetic Organic Chemistry (1953) Wagner et al. pp. 95, 566, 567.

Affiliated with

Also associated with

Rating

3-Halomethylcarbonyl-9-benzoyl-1,2,3,4-tetrahydrocarbazoles does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3-Halomethylcarbonyl-9-benzoyl-1,2,3,4-tetrahydrocarbazoles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-Halomethylcarbonyl-9-benzoyl-1,2,3,4-tetrahydrocarbazoles will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1277789