3-Halo cephalosporins

Details 3-Halo cephalosporins 3-Halo cephalosporins

1979-10-12

1981-02-24

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424246, 544 22, C07D50120

Patent

active

042529506

ABSTRACT:
7-Acylamido- and 7-amino-3-halo-3-cephem-4-carboxylic acids, esters and pharmaceutically-acceptable salts and esters thereof are new cephalosporin compounds provided by the reaction of a 7-acylamido-3-hydroxy-3-cephem-4-carboxylic acid ester or a 7-amino-3-hydroxy-3-cephem-4-carboxylic acid ester with an iodinating, fluorinating, chlorinating, or brominating reagent. For example, 7-amino-3-chloro-3-cephem-4-carboxylic acid and 7-phenoxyacetamido-3-chloro-3-cephem-4-carboxylic acid are provided. The 7-acylamido-3-halo cephalosporin acids and pharmaceutically acceptable salts and esters provided are valuable antibiotic compounds having desirable therapeutic properties.

REFERENCES:
patent: 3258461 (1966-06-01), Coucer
patent: 3705897 (1972-12-01), Mucohy
patent: 3925372 (1975-12-01), Chauvette
patent: 3926978 (1975-12-01), Koppel
patent: 3932398 (1976-01-01), Nudelman et al.
patent: 3962227 (1976-06-01), Chauvette
patent: 3963712 (1976-06-01), Koyama et al.
patent: 4064343 (1977-12-01), Chauvette
Cephalosporins and Penicillins, pp. 155-157, Academic Press, Edited by Flynn, Edw., (1972).

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