Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-06-10
1994-01-25
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540225, C07D50138, A61K 31545
Patent
active
052815897
ABSTRACT:
Novel semi-synthetic cephalosporin derivatives having a fused pyridiniummethyl at 3-position of the cephem nucleus, pharmaceutically acceptable salts, physiologically hydrolizable esters or solvates thereof are disclosed. Also disclosed is a process for preparing the cephalosporin derivatives which comprises introducing a fused pyridiniummethyl substituent at 3-position of 7-.beta.-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-cephem-ca rboxylic acid derivatives. The compounds of the present invention show potent antibacterial activities and a broad spectrum against both gram-positive and gram-negative bacteria.
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patent: 4152432 (1979-05-01), Heymes et al.
patent: 4258041 (1981-03-01), O'Callaghan et al.
patent: 4748172 (1988-05-01), Katner
Ahn Yang S.
An Seung H.
Cho Sung K.
Choi Kyoung E.
Kim Choong S.
Cheil Foods & Chemicals Inc.
Rizzo Nicholas S.
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