3-Fluoro-D-alanine and pharmacologically acceptable esters, and

Details 3-Fluoro-D-alanine and pharmacologically acceptable esters, and 3-Fluoro-D-alanine and pharmacologically acceptable esters, and

1974-08-05

1976-05-11

Raymond, Richard L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

204158R, 260534C, 424311, 424319, C07C10110, C07C10118, C07C10119

Patent

active

039563677

ABSTRACT:
3-Fluoro-D-alanine, its pharmacologically acceptable esters, and pharmacologically acceptable salts of the foregoing, as well as other pharmacologically acceptable derivatives of 3-fluoro-D-alanine which, when administered clinically, are effective in releasing 3-fluoro-D-alanine in vivo, are potent antibacterial agents, and are prepared by fluorination of D-alanine with fluoroxyperfluoroalkanes or fluoroxypentasulfur in the presence of a free radical initiator followed by esterification and/or treatment with acids or bases.

REFERENCES:
Yiian et al., Chemical Abstracts, Vol. 54, (1960), 12096i to 12097f.
Lettre et al., Chemical Abstracts, Vol. 68, (1968), 22229n.

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