Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-07-17
1998-11-17
Chang, Ceila
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31445, C07D40114
Patent
active
058377158
ABSTRACT:
A class of substituted 3-fluoro-4-aminopiperidine derivatives are selective agonists of 5-HT.sub.1 -like receptors, being potent agonists of the human 5-HT.sub.1D.sbsb..alpha. receptor subtype whilst possessing at least a 10-fold selective affinity for the 5-HT.sub.1D.sbsb..alpha. receptor subtype relative to the 5-HT.sub.1D.sbsb..beta. subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT.sub.1D receptors is indicated, while eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT.sub.1D receptor agonists.
REFERENCES:
patent: 5576336 (1996-11-01), Baker et al.
patent: 5637593 (1997-06-01), Porter et al.
patent: 5708008 (1998-01-01), Audia
Pineiro J. L. Castro
Russell M. G.
Chang Ceila
Durette Philippe L.
Merck Sharp & Dohme Ltd.
Winokur Melvin
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