3'-fluoro-3'-deoxykanamycin A

Details 3'-fluoro-3'-deoxykanamycin A 3'-fluoro-3'-deoxykanamycin A

1985-07-25

1987-01-06

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 137, A61K 3171, C07H 1522

Patent

active

046346880

ABSTRACT:
A new compound, 3'-fluoro-3'-deoxykanamycin A is now provided, which is active against gram-negative and gram-positive bacteria, including kanamycin-resistant strains of bacteria and is useful as antibacterial agent for therapeutic treatment of bacterial infections. This new compound is produced by a process comprising reacting a 6-azido-2,4-di-O-protected-3,6-dideoxy-3-fluoro-.alpha.-D-glucopyranosyl bromide with the 4-hydroxyl group of a 6-O-(2'-O-protected-3'-N-protected-3'-amino-4',6'-di-O-protected-3'-deoxy- .alpha.-D-glucopyranosyl)-1,3-bis-N-protected-2-deoxystreptamine, reducing the azido group of the resulting reaction product into an amino group, and removing the remaining protective groups from the reduction product.

REFERENCES:
patent: 4349666 (1982-09-01), Umezawa et al.
patent: 4357466 (1982-11-01), Umezawa et al.

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