3-ether and 3-thioether substituted cyclosporin derivatives...

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Cyclic peptides

Reexamination Certificate

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C514S011400

Reexamination Certificate

active

11241650

ABSTRACT:
This invention relates to cyclosporin derivatives of general formula (I):wherein A, B, R1, R2and X are as defined in the specification, and pharmaceutical compositions prepared from the same, for use in treatment of hepatitis C virus.

REFERENCES:
patent: 4703033 (1987-10-01), Seebach
patent: 4771122 (1988-09-01), Seebach
patent: 4798823 (1989-01-01), Witzel
patent: 4814323 (1989-03-01), Andrieu et al.
patent: 4885276 (1989-12-01), Witzel
patent: 4996193 (1991-02-01), Hewitt et al.
patent: 5294604 (1994-03-01), Nussenblatt
patent: 5948755 (1999-09-01), Barriere et al.
patent: 5948884 (1999-09-01), Luchinger
patent: 5965527 (1999-10-01), Barriere et al.
patent: 5977067 (1999-11-01), Evers et al.
patent: 5981479 (1999-11-01), Ko et al.
patent: 5994299 (1999-11-01), Barriere et al.
patent: 6254860 (2001-07-01), Garst
patent: 6350442 (2002-02-01), Garst
patent: 6444643 (2002-09-01), Steiner et al.
patent: 6521595 (2003-02-01), Kim et al.
patent: 6583265 (2003-06-01), Ellmerer-Muller et al.
patent: WO98/28328 (1998-07-01), None
patent: WO98/28329 (1998-07-01), None
patent: WO98/28330 (1998-07-01), None
patent: WO0001715 (2000-01-01), None
patent: WO2005/021028 (2005-03-01), None
patent: WO2006/005610 (2006-01-01), None
patent: WO06038088 (2006-04-01), None
Hansson et al., 2004, “The Nonimmunosuppressive Cyclosporin Analogs NIM811 and UNIL025 Display Nanomolar Potencies on Permeability Transition in Brain Derived Mitochondria,”Journal of Bioenergetics and Biomembranes, 36(4):407-413.
Hubler et al., 2000, “Synthetic Routes to NEtXaa4-Cyclosporin A Derivatives as Potential Anti-HIV I Drugs,”Tetrahedron Letters41(37):7193-7196.
Inoue et al., 2005, “Interferon Combined with Cyclosporin Treatment as an Effective Countermeasure Against Hepatitis C Virus Recurrence in Liver Transplant Patients with End-Stage Hepatitis C Virus Related Disease,”Transplantation Proceedings.37(2):1233-1234.
Xia et al., 2005, “Inhibitory Effect of Cyclosporine A on Hepatitis B Virus Replicationin Vitroand its Possible Mechanisms,”Hepatobiliary&Pancreatic Diseases International, 4(1):18-22.
DebioPharm Press Release, New Data Presented on Debiopharm's Debio-25 at the 11thInternational Symposium on the Hepatitis C Virus and Related Viruses in Heidelberg, Germany, Oct. 6, 2004.
Nakagawa et al., 2004, “Specific inhibition of hepatitis C virus replication by cyclosporin A,”Biochem. Biophys. Res. Commun.313:42-7.
Watashi et al., 2003, “Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes,”Hepatology38:1282-1288.
Shimotohno and Watashi, 2004,American Transplant Congress, Abstract No. 648 (American Journal of Transplantation, 2004, 4(s8):1-653).

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