3'-epimeric K-252A derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514213, 540543, 540546, A61K 3155, C07D49822

Patent

active

060937130

ABSTRACT:
Compounds defined by the following general structure are disclosed: ##STR1## These compounds display pharmacological activities, including inhibition of tyrosine kinase activity and enhancement of the function and/or survival of trophic factor responsive cells, e.g., cholinergic neurons.

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Kaneko et al., J. Med. Chem. 1997, 40, pp. 1863-1869.
Kinugawa, M. et al., "Synthetic Process Development of Antitumor Agent KT6587, an Indolocarbazole Alkaloid K252a Derivative, " Org. Proc. Res. Devel., 1999, 3, 131-134.
Nakanishi, S. et al., "K-252b, c and d, potent inhibitors of protein Kinase C from microbial origin," J. Antibiotics, 1986, vol. XXXIX(8), 1066-1071.
Sezaki, M. et al., "A new antibiotic SF-2370 produced by actinomadura," J. Abtibiotics, 1985, vol. XXXVIII(10), 1437-1439.

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