3-(Disubstituted)aminoisothiazolo[3,4-d]pyrimidines

Details 3-(Disubstituted)aminoisothiazolo[3,4-d]pyrimidines 3-(Disubstituted)aminoisothiazolo[3,4-d]pyrimidines

1976-03-03

1977-10-04

Schenkman, Leonard

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

2602565R, C07D51304

Patent

active

040523918

ABSTRACT:
Novel 3-(disubstituted)aminoisothiazolo[3,4-d]pyrimidines of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are respectively alkyl, alkenyl, aryl, aralkyl or aralkenyl, each of which may be substituted, or R.sup.1 and R.sup.2 form together with the adjacent nitrogen a heterocyclic ring which may be substituted, R.sup.4 is hydrogen or alkyl and X is oxygen or imino with a proviso that when X is imino R.sup.4 is hydrogen, show an eminent adenosine-3',5'-cyclic phosphate phosphodiesterase-inhibitory activity, and exhibit excellent pharmacological actions such as anti-inflammatory and sedative activities.

REFERENCES:
patent: 3674786 (1972-07-01), Rajappa
patent: 3959280 (1976-05-01), Furukawa et al.

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