3-diphenyl substituted octahydroindolizine analgesic compounds

Details 3-diphenyl substituted octahydroindolizine analgesic compounds 3-diphenyl substituted octahydroindolizine analgesic compounds

1986-04-10

1987-07-28

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546112, 546334, 546335, 546337, 546340, 546342, A61K 31445, C07D22104

Patent

active

046832394

ABSTRACT:
Octahydroindolizine compounds of formula (I): ##STR1## wherein Q is --NR--, --(CH.sub.2).sub.z --, --CH.dbd.CH--, --C.tbd.C--, --OCH.sub.2 --, --SCH.sub.2 --, --SO.sub.2 --, --SO--, --CO--, or an oxygen or a sulfur atom and where R, R.sup.1 and R.sup.2 are substituents such as alkyl and x, y and z are independently the integers 0-3. Also, pharmaceutical compositions containing (I), intermediates and methods for treating pain.

REFERENCES:
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"Studies on Psychotropic Agents . . . " Chem. Pharm. Bull. 27(5), pp. 1159-1168, Yasutaka Nagai et al., 1979.
"Addition von Aldehyden . . . ", J. Heterocyclic Chem. 14, pp. 573-581, Hermann Stetter et al., Jun. 1977.
"The Structures and Spectral Properties . . . ", vol. 31, pp. 4215-4220, Manfred G. Reinecke et al., Dec. 1966.
"3-Arylquinolizidines, Potential Antidepressant Agents", J. Med. Chem., vol. 18, No. 11, pp. 1126-1130, M. E. Rogers et al., 1975.
"A Synthesis of Octahydropyrrocolines", J. Proc. Royal Soc., vol. 73, pp. 240-252, Francis Lions et al., 1940.

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