3'-derivatized oligonucleotide analogs with non-nucleotidic grou

Details 3'-derivatized oligonucleotide analogs with non-nucleotidic grou 3'-derivatized oligonucleotide analogs with non-nucleotidic grou

1993-01-19

1997-07-08

Guzo, David

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 245, C07H 2104

Patent

active

056462611

ABSTRACT:
The present invention relates to novel oligonucleotide analogs with valuable physical, biological and pharmacological properties, and a process for their preparation.

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Koga, Masakazu, et al., The Journal of Organic Chemistry "Alternating .alpha., .beta.-oligothymidylates with alternating (3'-3')-and (5'-5')-internucleotidic phosphodiester linkages as models for antisense oligodeoxyribonucleotides," 56(12): 3757-3759, (1991).
Shaw, et al., Nucleic Acids Research, "Deoxyoligunucleotides stable to exonuclease degradation in serum," 19(4): 747-750, (1991).
Goodchild, John, Bioconjugate Chemistry, "Conjugates of oligonucleotides and modified oligonucleotides: a review of their synthesis and properties," 1(3): 165-186, (1990).
Uhlmann, E., et al., Chemical Reviews, "Antisense oligonucleotides: a new therapeutic principle," 90(4): 543-584, (1990).
Thuong, N.T., et al., Bulletin de la Societe Chimique de France, "Nouvelle methods de preparation d'esters phosphoriques, renfermant un groupe .beta.-mercaptoethyle, utilisables en synthese nucleotidique," 1-2, pp. II-51-II-56 (1981).

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