3"-Deoxystreptomycin production thereof and pharmaceutical compo

Details 3"-Deoxystreptomycin production thereof and pharmaceutical compo 3"-Deoxystreptomycin production thereof and pharmaceutical compo

1983-03-09

1984-09-25

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 14, 536 15, 536 16, A61K 3171, C07H 1522

Patent

active

044735570

ABSTRACT:
A new semi-synthetic antibiotic, 3"-deoxystreptomycin is now provided, which is useful as an antibacterial agent and is produced from 3"-deoxydihydrostreptomycin by a process comprising oxidizing the 3'-hydroxymethyl group of 2,5,6,4",6"-penta-O-acetyl-2"-N-benzyloxycarbonyl-3"-deoxydihydrostreptomy cin as prepared by skilled introduction of amino-protecting group and hydroxyl-protecting group of appropriately selected natures into 3"-deoxydihydrostreptomycin, and then removing the protective groups from the oxidation product, 2,5,6,4",6"-penta-O-acetyl-2"-N-benzyloxycarbonyl-3"-deoxystreptomycin.

REFERENCES:
patent: 2663685 (1953-12-01), Levy
patent: 2790792 (1957-04-01), Kaplan
patent: 2857375 (1958-10-01), Ziegler
patent: 4171356 (1979-10-01), Wright et al.

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