3-deoxyglucosone derivatives

Details 3-deoxyglucosone derivatives 3-deoxyglucosone derivatives

1994-09-29

1997-05-27

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

436 63, C07H 300, C07H 302

Patent

active

056333560

ABSTRACT:
For determining 3-deoxyglucosone derivatives which are intermediate metabolites of the Maillard reaction in body fluids such as blood, urine, serum, plasma and the like in gas chromatography/mass spectrometry, .sup.13 C-labelled compounds or .sup.14 C-labelled compounds are useful as an internal standard substance. More specifically, 3-deoxyglucosone derivatives having the formula (I): ##STR1## wherein *C is .sup.13 C or .sup.14 C, X is O or N--OR wherein R is Me, Et or H, and Y is SiMe.sub.3 or SiMe.sub.2 tBu, and their production are provided. The measurement of 3-deoxyglucosone derivatives is useful in diagnosing diseases such as diabetes and diseases complicated with diabetes, including diabetic nephrosis, various renal disorders, renal insufficiency, metabolic diseases of carbohydrate and the like.

REFERENCES:
patent: 5302758 (1994-04-01), Larson et al.
"Chemical Abstracts", C. Paul Blanchi, vol. 113, No. 13, p. 89, 1990.
"Detection of 3-Deoxyfructose and 3-Deoxyglucosone in Human Urine and Plasma: Evidence for Intermediate Stages of Maillard Reaction in Vivo.sup.1 ", Knecht et al., Archives of Biochemistry and Biophysics, vol. 294, No. 1, Apr., pp. 130-137, 1992.
Kato et al. Biochim. Biophys. Acta 1035:71-76, 1990.
Khadem et al. Carbo. Res. 17:183-192, 1971.
Shinoda et al. in The Maillard Reaction. Advances in Life Sciences, 1990 Birkh auser Verlag Basel, pp. 309-314.
Chem. Abstracts 1986: 605466, Drijver et al. J. Caromatog. 363: 345-52, 1986.

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