3-Demethylmevalonic acid derivatives, a process for their prepar

Details 3-Demethylmevalonic acid derivatives, a process for their prepar 3-Demethylmevalonic acid derivatives, a process for their prepar

1989-03-08

1990-04-03

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549 60, 549292, 549472, 549417, 546268, 560 53, A61K 31365, C07D30930

Patent

active

049141279

ABSTRACT:
3-Demethylmevalonic acid derivatives of the formula I (.delta.-lactone) and Ia (corresponding dihydroxycarboxylic acid derivative) ##STR1## in which A-B, Z, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the indicated meanings, a process for the preparation of these compounds, their use as medicaments and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I and Ia are described.

REFERENCES:
patent: 4440927 (1984-04-01), Prugh
patent: 4588715 (1986-05-01), Damon, II
patent: 4622338 (1986-11-01), Baran et al.
patent: 4710513 (1987-12-01), Willard et al.
Stokker et al., "3-Hydroxy-3-methylglutaryl-etc", J. Med. Chem., (1986), 29, 170-181.
Chemical Abstract No. 99: 38364d, 1983.

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