3-demethyl-4-fluoromevalonic acid derivatives, a process for the

Details 3-demethyl-4-fluoromevalonic acid derivatives, a process for the 3-demethyl-4-fluoromevalonic acid derivatives, a process for the

1988-07-08

1990-02-06

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514256, 514336, 514422, 514427, 514438, 514444, 514460, 514461, 514568, 544335, 546268, 546342, 548517, 549 60, 549 79, 549292, 549501, A61K 3144, C07D21335, C07D40506

Patent

active

048988685

ABSTRACT:
3-Demethyl-4-fluoromevalonic acid derivatives, a process for the preparation thereof, pharmaceutical products based on these compounds, the use thereof, and intermediates
3-Demethyl-4-fluoromevalonic acid derivatives of the formula I, and the corresponding dihydroxy carboxylic acid derivatives of the formula II ##STR1## in which R, X and Y have the stated meanings, processes for the preparation of these compounds, the use thereof as medicaments, and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I and formula II are described.

REFERENCES:
patent: 4657918 (1987-04-01), Findlay et al.
patent: 4812460 (1989-03-01), Lazer
Endo et al.; "ML-236A, ML-236B, and ML-236C, New Inhibitors of Cholesterogenesis Produced by Penicillium Citrinum"; The Journal of Antibiotics; vol. XXIX No. 12; (1976); pp. 1346-1348.
Brown et al.; "Crystal and Molecular Structure of Compactin, a New Antifungal Metabolite from Penicillium brevicompactum"; J.C.S., Perkins, I; (1976); pp. 1165-1170.
Stokker et al.; "Synthesis and X-Ray Characterization of 6(S)-Epi-Mevinolin, a Lactone Epimer", J. Org. Chem.; (1986); vol. 51; pp. 4931-4934.

Affiliated with

Also associated with

Rating

3-demethyl-4-fluoromevalonic acid derivatives, a process for the does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3-demethyl-4-fluoromevalonic acid derivatives, a process for the, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-demethyl-4-fluoromevalonic acid derivatives, a process for the will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-441993