3-Demethoxyistamycin B, the 2"-N-formimidoyl derivative thereof

Details 3-Demethoxyistamycin B, the 2"-N-formimidoyl derivative thereof 3-Demethoxyistamycin B, the 2"-N-formimidoyl derivative thereof

1983-10-26

1984-10-30

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 161, 536 168, 536 181, A61K 3171, C07H 1522

Patent

active

044799438

ABSTRACT:
As new compounds are provided 3-demethoxyistamycin B and 3-demethoxy-2"-N-formimidoylistamycin B which each is useful as antibacterial agent because of its high antibacterial activity against a wide variety of gram-positive and gram-negative bacteria including mycobacteria. These new compounds may be produced by removal of the 3-hydroxyl group of an N,O-protected 3-O-demethylistamycin B.sub.o, followed by glycylation of the liberated 4-methylamino group and, further, if necessary, followed by formimidoylation of the 2"-amino group of an intermediate N-protected 3-demethoxyistamycin B derivative.

REFERENCES:
patent: 4232147 (1980-11-01), Tadanier et al.
patent: 4382926 (1983-05-01), Umezawa et al.
patent: 4406891 (1983-09-01), Umezawa et al.

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