3-deazaneplanocin, intermediates for it, and antiviral compositi

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546118, 546296, 546297, 546301, 514258, 514261, 514262, 514267, 514241, 514245, 514274, 544220, 544223, 544254, 544251, 544264, 544276, 544277, 544314, 544317, 544318, 549437, 549438, A61K 3152, C07D47104

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active

049686909

ABSTRACT:
The new compound 3-deazaneplanocin A has been discovered to have potent anti-viral, anti-tumor activity and differentiating activity. A simple method for preparing 3-deazaneplanocin A has been developed involving nucleophilic substitution, which method can also be used to prepare a great variety of carbocyclic nucleosides.

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Montgomery, et al., Chemical Abstracts, vol. 96:192972v (1982).
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Glazer, et al., Biochem. Biophys. Res. Commun. 1986. 135(2), pp. 688-694, Chemical Abstracts, vol. 104:199696a supplied U.S. Dept HHS, Chemical Abstracts, vol. 106:5380r (1987).

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