3-Deazaadenosine as an inhibitor of adenosylhomocysteine hydrola

Details 3-Deazaadenosine as an inhibitor of adenosylhomocysteine hydrola 3-Deazaadenosine as an inhibitor of adenosylhomocysteine hydrola

1978-03-13

1979-04-10

Rosen, Sam

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

195 17, 195 18, 195 63, A61K 3170, C12B 900, C12L 100

Patent

active

041488881

ABSTRACT:
3-Deazaadenosine has been found to be an effective antiviral and antifocal agent in tissue culture of animals as evidenced by its activity against Rous sarcoma virus, influenza virus, vesicular stomatitis virus, Sindbis virus, and Newcastle disease virus in the range 0.03-0.3 mM. This compound has also shown use as an inhibitor of adenosylhomocysteine hydrolase from beef liver in the range of 0.001-0.008 mM (I.sub.50). The antiviral and antifocal effect is correlated with the inhibition of hydrolysis of adenosylhomocysteine in cells. This inhibition of adenosylhomocysteine hydrolase can also be demonstrated in livers of rats injected with 3-deazaadenosine.

REFERENCES:
chem. Abst. 9th Coll. Index, vol. 76-85, (1972-1976), p. 19488cs.

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