3'-Deamino-3'-morpholino carminomycin

Details 3'-Deamino-3'-morpholino carminomycin 3'-Deamino-3'-morpholino carminomycin

1982-03-15

1983-02-22

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, A61K 3171, C07H 1524

Patent

active

043749801

ABSTRACT:
Disclosed is 3'-deamino-3'-morpholino-carminomycin, a new anthracycline glycoside having both antimicrobial and antitumor activity. Also disclosed is a new N-alkylation procedure for preparing the above compound as well as the known anthracyclines, 3'-deamino-3'-morpholino-adriamycin and 3'-deamino-3'-morpholino-daunomycin, in high yield.

REFERENCES:
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patent: 3988315 (1976-10-01), Umezawa et al.
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patent: 4301277 (1981-11-01), Acton et al.
patent: 4302449 (1981-11-01), El Khadem et al.
patent: 4303785 (1981-12-01), Umezawa et al.
patent: 4314054 (1982-02-01), Acton et al.
Gause et al., "Cancer Chemotherapy Report Part 1", vol. 58, No. 2, Mar./Apr., 1974, pp. 255-256.

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