3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxo

Details 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxo 3-Deamino-3-(4-morpholinyl) derivatives of daunorubicin and doxo

1980-10-20

1981-11-17

Hazel, Blondel

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, C07H 1524

Patent

active

043012779

ABSTRACT:
Described are 3'-deamino-3'-(4-morpholinyl) derivatives of daunorubicin and doxorubicin having the formula ##STR1## wherein R is COCH.sub.3 or --CHOHCH.sub.3 in the case of daunorubicin derivatives, or is --COCH.sub.2 OH or --CHOHCH.sub.2 OH in the case of doxorubicin derivatives together with their pharmaceutically acceptable acid addition salts. The compounds have utility as antitumor agents.

REFERENCES:
patent: 4202967 (1980-05-01), Tong et al.
patent: 4250303 (1981-02-01), Wu et al.

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