3'-Deamino-3'-(4-methoxy-1-piperidinyl) derivatives of daunorubi

Details 3'-Deamino-3'-(4-methoxy-1-piperidinyl) derivatives of daunorubi 3'-Deamino-3'-(4-methoxy-1-piperidinyl) derivatives of daunorubi

1981-03-23

1982-02-02

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, A61K 3170, C07H 1524

Patent

active

043140548

ABSTRACT:
Described are 3'-deamino-3'-(4-methoxy-1-piperidinyl) derivatives of daunorubicin and doxorubicin having the formula ##STR1## wherein R is COCH.sub.3 or --CHOHCH.sub.3 in the case of daunorubicin derivatives, or is COCH.sub.2 OH or --CHOH--CH.sub.2 OH in the case of doxorubicin derivatives together with their pharmaceutically acceptable acid salts. The compounds have utility as antitumor agents.

REFERENCES:
patent: 4035566 (1977-07-01), Israel et al.
patent: 4177264 (1979-12-01), Wu et al.
patent: 4202967 (1980-05-01), Tong et al.
patent: 4250303 (1981-02-01), Wu et al.
Henry, Reprint from 'ACS Symposium Series, No. 30, "Cancer Chemotherapy", 1979, pp. 15-57.
Tong et al. "Jour. of Medicinal Chem." vol. 22, No. 8, 1979, pp. 912-918.

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