3'-deamino-3'-(2"-substituted-4"-morpholino)-anthracycline compo

Details 3'-deamino-3'-(2"-substituted-4"-morpholino)-anthracycline compo 3'-deamino-3'-(2"-substituted-4"-morpholino)-anthracycline compo

1989-08-29

1990-09-25

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1524

Patent

active

049594605

ABSTRACT:
Disclosed is an anthracycline compound of the formula (I): ##STR1## wherein Ra is -R.sup.1, ##STR2## or --OR.sup.3, R.sup.1 being (1) alkyl, alkenyl, alkynyl, fluoroalkyl, aryl or aralkyl, or (2) alkyl, alkenyl, alkynyl. fluoroalkyl, aryl or aralkyl having carboxyl, azido, amino, hydroxy, alkoxy or a halogen atom; R.sup.2 being R.sup.1, a hydrogen atom or hydroxy; and R.sup.3, which may be the same or different when one substituent has two R.sup.3 's, being R.sup.1 or a hydrogen atom; or the formula (II): ##STR3## wherein Rb is -R.sup.1, ##STR4## or --OR.sup.3, R.sup.1, R.sup.2 and R.sup.3 being as defined above; and R.sup.4 being the same as R.sup.3 except that methyl is not included; or an acid addition salt thereof.
This compound can be contained as an active ingredient in an antitumor agent, whereby good results are attainable.

REFERENCES:
patent: 4710564 (1987-12-01), Otake et al.

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