3-DE-O-Methylfortimicins

Details 3-DE-O-Methylfortimicins 3-DE-O-Methylfortimicins

1976-12-27

1978-11-07

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 424181, 536 4, C07H 1522

Patent

active

041247566

ABSTRACT:
Described are 3-de-O-methylfortimicins A and B and 4-N-acyl and 4-N-alkyl-3-de-O-methylfortimicin B derivatives, and their preparation, which compounds are useful as antibiotics or as intermediates for preparing other useful derivatives having antibacterial activity. The compounds have the following structural formula ##STR1## wherein R is hydrogen, acyl, aminoacyl, N-monoloweralkylaminoacyl, N.N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, alkyl, aminoalkyl, N-monoloweralkylaminoalkyl, N.N-diloweralkylaminoalkyl or hydroxy-substituted aminoalkyl and the pharmaceutically acceptable salts thereof, for example, salts formed from hydrochloric, sulfuric, and phosphoric acids.

REFERENCES:
patent: 3350387 (1967-10-01), Vanderhaeghe
patent: 3792037 (1974-02-01), Kawaguchi et al.
patent: 3925353 (1975-12-01), Umezawa et al.
patent: 3985727 (1976-10-01), Daniels

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