3-Cyano indoles as intermediates for cardioselective compounds

Details 3-Cyano indoles as intermediates for cardioselective compounds 3-Cyano indoles as intermediates for cardioselective compounds

1981-07-29

1984-04-10

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548492, 548493, 548495, C07D20904

Patent

active

044422954

ABSTRACT:
The present invention provides indole derivatives of the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom, an aralkyl radical or a radical of the general formula: ##STR2## in which B is a reactive group or, together with R.sub.5, represents a valency bond, and R.sub.5 is a hydrogen atom or an aliphatic or aromatic acyl radical, R.sub.2 is a hydrogen atom or a lower alkyl radical, R.sub.3 is a hydrogen atom, a methyl radical or a --CH.sub.2 --O--R.sub.5 radical, R.sub.5 having the same meaning as above, and R.sub.4 is an aminocarbonyl, cyano, oximinomethyl, formyl, hydroxymethyl or lower alkoxycarbimidoyl radical, with the proviso that R.sub.1 is not an aralkyl radical when R.sub.4 is a formyl radical. The present invention also provides processes for the preparation of these compounds. Furthermore, the present invention is concerned with the use of these compounds for the preparation of compounds with a heart and circulatory activity.

REFERENCES:
patent: 3072530 (1963-01-01), Hofmann et al.
patent: 3226399 (1965-12-01), Allen et al.
Can. J. Chem., 42, 514/1964.

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