3-cyano-5,4'-bipyridine-1'-oxide compounds and pharmaceutical co

Details 3-cyano-5,4'-bipyridine-1'-oxide compounds and pharmaceutical co 3-cyano-5,4'-bipyridine-1'-oxide compounds and pharmaceutical co

1991-03-07

1992-11-10

Ore, Dale R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544124, 544360, 546258, A61K 3144, A61K 31495, A61K 31535, C07D24916

Patent

active

051625334

ABSTRACT:
A 3-cyano-5,4'-bipyridine-1'-oxide of the formula ##STR1## and their pharmaceutically acceptable acid addition salts, wherein R is an amino, alkoxy, oxyalkoxy or chloro residue, have heart stimulating cardiotonic and vasodiolatory properties. They can be preparaed by (a) converting an R-substituted-3-cyano-bipyridine to its corresponding N-oxide, or (b) by substituting an R-residue or an R-unsubstituted precursor of the conpound of fomula (i), and if required, converting the product into its pharmaceutically acceptable acid addition salt.

REFERENCES:
patent: 4264603 (1981-04-01), Lesher et al.
patent: 4362734 (1982-12-01), Lesher et al.
patent: 4463008 (1984-07-01), Lesher et al.
Chemical Abstracts, vol. 79, No. 25, Abstract No. 145840q, p. 272, Dec. 24, 1973, Kireev et al.

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