3-Cyano-4-hydroxy coumarin derivatives

Details 3-Cyano-4-hydroxy coumarin derivatives 3-Cyano-4-hydroxy coumarin derivatives

1976-06-28

1977-06-28

Weinberger, Lorraine A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260465F, 424281, 424304, C07D31106

Patent

active

040325440

ABSTRACT:
Compounds of the formula ##STR1## and pharmaceutically acceptable, nontoxic salts thereof or hydrates thereof, wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each hydrogen, halogen, lower alkyl or lower alkoxy, or any two of the groups R.sub.1, R.sub.2, R.sub.3 and R.sub.4, taken together with the carbon atoms to which they are joined complete a substituted or unsubstituted carbocyclic ring, and X is an oxygen atom, provided that R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are not all simultaneously hydrogen, are useful for treating allergic conditions in humans.
The compounds may be prepared by reacting a suitably substituted benzene derivative with an activated carbonyl group having a carbanion of the formula NC-CH-R, wherein R is a carboxylic acid ester group, and thereafter, if desired, converting the compound into a salt.

REFERENCES:
patent: 3521187 (1970-07-01), Snavely et al.
Cecchi et al. Chemical Abstracts 65, 16931h, 1966.

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