Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1975-12-29
1976-08-31
Rizzo, Nicholas S.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
C07D26114
Patent
active
039780732
ABSTRACT:
A novel process for preparing 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide (I), starting with 3-amino-5-methylisoxazole (II) is disclosed. Compound I exhibits anti-inflammatory properties and is useful for treating inflammation. In the process of the invention an intermediate obtained, 2,3-dihydro-N-(5-methyl-3-isoxazolyl)-3-oxo-1,2-benzisothiazole-2-acetamid e 1,1-dioxide (IV) undergoes rearrangement to provide 1-{[5-(4-hydroxy-2H-1,2-benzothiazin-3-yl)-1,2,4-oxadiazol-3-yl]methyl}eth anone S,S-dioxide (V), which is methylated, according to conventional procedures. The methylated intermediates VI, upon further treatment, undergoes a second rearrangement to obtain the desired anti-inflammatory compound I.
Fabian Arthur C.
Genzer Jerome D.
Kasulanis Charles Francis
Shavel, Jr. John
Zinnes Harold
Chow Frank S.
Graddis Albert H.
Kelly Anne M.
Rizzo Nicholas S.
Springer D. B.
LandOfFree
3-(Chlorocetamido)-5-methyl isoxazole does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 3-(Chlorocetamido)-5-methyl isoxazole, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-(Chlorocetamido)-5-methyl isoxazole will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1815350