3-Chloroalkylcarbamoyloxymethy l-7-[2-(fur-2-yl)-2-methoxyiminoa

Details 3-Chloroalkylcarbamoyloxymethy l-7-[2-(fur-2-yl)-2-methoxyiminoa 3-Chloroalkylcarbamoyloxymethy l-7-[2-(fur-2-yl)-2-methoxyiminoa

1975-08-01

1977-03-08

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424246, C07D50120

Patent

active

040112152

ABSTRACT:
Cephalosporin antibiotics in which the 7.beta.-acylamido group is syn 2-furyl-2-methoxyiminoacetamido and in which the 3-position substituent is a chloroalkylcarbamoyloxymethyl group exhibit high antibacterial activity against a broad range of gram positive and gram negative organisms, particularly high stability to .beta.-lactamases produced by various organisms, and stability in vivo. The compounds are syn isomers or exist as mixtures of syn and anti isomers containing at least 90% of the syn isomer.

REFERENCES:
patent: 3573294 (1971-03-01), Long et al.
patent: 3946219 (1970-12-01), Long et al.

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