3-Chloro-tetrahydro-1,3-oxazines or oxazolidines spiro substitut

Details 3-Chloro-tetrahydro-1,3-oxazines or oxazolidines spiro substitut 3-Chloro-tetrahydro-1,3-oxazines or oxazolidines spiro substitut

1975-04-10

1976-02-03

Winters, Sherman D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260244R, 260307FA, C07D22120

Patent

active

039364666

ABSTRACT:
There is provided, novel 3-chloro-tetrahydro 1,3-oxazine or oxazolidine compounds, exhibiting antibacterial activity and being of low chlorine potential of the formula: ##EQU1## WHEREIN EACH OF R.sub.1 and R.sub.2, which may be the same or different, represent an alkyl group of from 1 to 20 carbon atoms (C.sub.1 -C.sub.5 being preferred); wherein each of R.sub.5 and R.sub.6, which may be the same or different, represent a hydrogen atom or an alkyl group of from 1 to 20 carbon atoms (C.sub.1 -C.sub.5 being preferred); wherein l represents an integer of 1 or 2 and wherein each of R.sub.3 and R.sub.4, which may be the same or different, represent an alkyl group of from 1 to 20 carbon atoms (C.sub.1 -C.sub.5 being preferred), a --(CH.sub.2).sub.n X group, wherein n represents an integer of from 1 to 20 and wherein X represents a dimethylamino group, a diethylamino group, a trimethylammonium group, a triethylammonium group, a dimethylammonium group, a diethylammonium group, a --COOR.sub.7 group, a --OOCR.sub.8 group, and a --OR.sub.9 group, wherein each of R.sub.7 through R.sub.9, respectively, represent an alkyl group of from 1 to 5 carbon atoms or a benzyl group. In addition, R.sub.3 and R.sub.4 can also represent a ##EQU2## group, wherein Y represents a --(CH.sub.2).sub.n --W--(CH.sub.2).sub.m -- group or a > CH--Z group, wherein W represents a --O-- atom, a --CH.sub.2 -- group, a > NCH.sub.3 -- group, a > NHCH.sub.3 .sup.+ group, a > NC.sub.2 H.sub.5 group, a > NHC.sub.2 H.sub.5 .sup.+ group, a > N(CH.sub.3).sub.2 .sup.+ group, or a > N(C.sub.2 H.sub.5).sub.2 .sup.+ group, wherein n is the same or different from m and wherein each of n and m represent an integer of from 0 to 2; and wherein Z is defined in accordance with X above.

REFERENCES:
patent: 3881908 (1975-05-01), Dorschner et al.

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