3-Chloro-6-(pyridinyl)-pyridazines

Details 3-Chloro-6-(pyridinyl)-pyridazines 3-Chloro-6-(pyridinyl)-pyridazines

1981-02-26

1982-10-12

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D40104

Patent

active

043540260

ABSTRACT:
3-Hydrazino-6-PY-pyridazine or pharmaceutically-acceptable acid-addition salt thereof is useful as a cardiotonic agent, where PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents. 6-PY-3-pyridazinol is prepared by reacting 6-PY-3-pyridazinol with a chlorinating agent to produce 3-chloro-6-PY-pyridazine and reacting said 3-chloro compound with hydrazine to produce said 3-hydrazino compound. 3-Hydrazino-6-PY-pyridazine or pharmaceutically-acceptable acid-addition salt thereof is disclosed as the active component in cardiotonic compositions for increasing cardiac contractility and in the method for increasing cardiac contractility in a patient requiring such treatment. The novel intermediate 3-chloro-6-PY-pyridazine is prepared as noted above.

REFERENCES:
Anderson et al., Chem. Abs. 77, 114418n, (1971).
Petric, Chem. Abs. 84, 74205b, (1975).
Rosseels et al., Chem. Abs. 64, 12474e, (1966).

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