Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1993-05-17
1994-10-18
Morgan, Kriellion S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514126, 514128, C08K 515
Patent
active
053569660
ABSTRACT:
Compounds of the formula (1), ##STR1## in which R.sub.2, R.sub.3, R.sub.4 and R.sub.5, independently of one another, are hydrogen, C.sub.1 -C.sub.25 alkyl, C.sub.7 -C.sub.9 phenylalkyl, unsubstituted or C.sub.1 -C.sub.4 alkyl-substituted phenyl, unsubstituted or C.sub.1 -C.sub.4 alkyl-substituted C.sub.5 -C.sub.8 cycloalkyl; C.sub.1 -C.sub.18 alkoxy, hydroxyl, C.sub.1 -C.sub.25 alkanoyloxy, C.sub.3 -C.sub.25 alkenoyloxy, C.sub.3 -C.sub.25 alkanoyloxy which is interrupted by oxygen, sulfur or >N--R.sub.13 ; C.sub.6 -C.sub.9 cycloalkylcarbonyloxy, benzoyloxy or C.sub.1 -C.sub.12 alkyl-substituted benzoyloxy, in which R.sub.13 is hydrogen or C.sub.1 -C.sub.18 alkyl, or furthermore the radicals R.sub.2 and R.sub.3 or the radicals R.sub.4 and R.sub.5 together with the carbon atoms to which they are bonded form a phenyl ring, R.sub.4 is additionally (CH.sub.2).sub.n --COR.sub.14, in which n is 0, 1 or 2, R.sub.14 is hydroxyl, ##EQU1## C.sub.1 -C.sub.18 alkoxy or ##STR2## R.sub.15 and R.sub.16, independently of one another, are hydrogen or C.sub.1 -C.sub.18 alkyl, M is an r-valent metal cation and r is 1, 2 or 3, R.sub.7, R.sub.8, R.sub.9 and R.sub.10, independently of one another, are hydrogen, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy, with the proviso that at least one of the radicals R.sub.7, R.sub.8, R.sub.9 and R.sub.10 is hydrogen, R.sub.11 and R.sub.12, independently of one another, are hydrogen, C.sub.1 -C.sub.4 alkyl or phenyl, and, in the case where R.sub.3, R.sub.5, R.sub.6, R.sub.7 and R.sub.10 are hydrogen, R.sub.4 is additionally a radical of the formula (2), ##STR3## in which R.sub.2, R.sub.8, R.sub.9, R.sub.11 and R.sub.12 are as defined above and R.sub.1 is as defined below for m=1 and R.sub.17 and R.sub.18, independently of one another, are hydrogen, C.sub.1 -C.sub.12 alkyl or phenyl, or R.sub.17 and R.sub.18 together with the carbon atom to which they are bonded form a C.sub.5 -C.sub.7 cycloalkylidene ring which is unsubstituted or substituted by 1 to 3 C.sub.1 -C.sub.4 alkyl, m is an integer from the range of 1 to 6, and, in the case where m is 1, R.sub.1 is hydroxyl, C.sub.1 -C.sub.30 alkoxy, C.sub.3 -C.sub.30 alkoxy which is interrupted by oxygen, sulfur or >N--R.sub.13 ; C.sub.7 -C.sub.9 phenylalkoxy, C.sub.5 -C.sub.12 cycloalkoxy, C.sub.2 -C.sub.18 alkenyloxy, unsubstituted or C.sub.1 -C.sub.12 alkyl-substituted phenoxy, ##STR4## R.sub.16, r and M are as defined above, R.sub.19 and R.sub.20, independently of one another, are C.sub.1 -C.sub.4 alkyl, p is 1 or 2, and R.sub.6 is hydrogen or a radical of the formula (3), ##STR5## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.7, R.sub.8 R.sub.9, R.sub.10, R.sub.11 and R.sub.12 are as defined above, are described as stabilizers for organic materials against thermal, oxidative or light-induced degradation.
REFERENCES:
patent: 4325863 (1982-04-01), Hinsken et al.
patent: 4338244 (1982-07-01), Hinsken et al.
patent: 5308899 (1994-05-01), Michaelis
W. Bradley, et al., J. Chem. Soc. 1956, 1622.
Organikum 1986 pp. 194-200.
Houben-Weyl Methoden der organischen Chemie, vol. 6/1C, 1030.
Organikum 1986, pp. 402-410.
Ciba-Geigy Corporation
Hall Luther A. R.
Morgan Kriellion S.
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