3-Carbamoyloxymethyl or N-methyl-carbamoyloxymethyl-7-[2-carboxy

Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424246, 544 25, 544 27, 544 28, 544 17, 542442, 2603474, 2603473, 2603322A, C07D50134, A61K 31545

Patent

active

040950212

ABSTRACT:
Cephalosporin antibiotics in which the 7.beta.-acylamido group has the structure ##STR1## (where R is thienyl or furyl; R.sup.a and R.sup.b are each selected from hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.3-7 cycloalkyl, phenyl, naphthyl, thienyl, furyl, carboxy, C.sub.2-5 alkoxycarbonyl and cyano, or R.sup.a and R.sup.b together with the carbon atom to which they are attached form a C.sub.3-7 cycloalkylidene or cycloalkenylidene group; and m and n are each 0 or 1 such that the sum of m and n is 0 or 1) exhibit broad spectrum antibiotic activity characterized by particularly high activity against gram negative microorganisms, including those which produce .beta.-lactamases. The compounds, which are syn isomers or exist as mixtures of syn and anti isomers containing at least 90% of the syn isomer, have particularly high in vitro activity against strains of Escherichia coli, Haemophilus influenzae and Proteus organisms; compounds wherein at least one of R.sup.a and R.sup.b is other than hydrogen have also shown unusually high activity against Pseudomonas organisms. Important compounds of the above type include those in which the 7.beta.-acylamido group is a syn-2-carboxymethoxy-2-(fur-2-yl)acetamido, syn-2-(2-carboxyprop-2-yloxyimino)-2-(fur-2-yl)acetamido or syn-2-(1-carboxycyclopent-1-yloxyimino)-2-(fur-2-yl)acetamido group.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

3-Carbamoyloxymethyl or N-methyl-carbamoyloxymethyl-7-[2-carboxy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 3-Carbamoyloxymethyl or N-methyl-carbamoyloxymethyl-7-[2-carboxy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 3-Carbamoyloxymethyl or N-methyl-carbamoyloxymethyl-7-[2-carboxy will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-10444

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.